I think you'd need to write a driver on the PC.

I came across WinDriver (not to be confused with Wind River, the RTOS people) a while back, which claims to be a Device Driver Writing Toolkit.
You could probably do it with this, but I think you'd end up having to get quite deeply into Windows/PC System programming...?

Here's some blurb I rececived:
"WinDriver
Jungo have a range of products that not only allows you to test your hardware interactively but to write your driver in User Mode instead of Kernel mode. As a bonus the same driver code can create drivers for W95, W98,ME, 2000, NT, XP, CE, Linux and even VxWorks. Both C++ and Delphi application environments are supported.

WinDriver allows you to write user mode code that will control I/O, memory and interrupts which are interfaced via most bus architectures: PCI, PCMCIA(CE only), ISA, ISA PnP and EISA. Enhanced support for the most popular PCI bridge chips ( PLX, V3, Galileo, Altera, QuickLogic, PLDA and AMCC ) shields the developer from their complexity.

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