Just a question: Why would you want to do this?
I understand the urge to pick-up some old stuff and play around. What I don't understand is: Why take an out-dated chip, needing all sort of other chips to do it's job. If you need speed, there are lots of (better) solutions for that with chips that are still supported. If you want a cheap board, leave it the way it is and get it to work. If you want a really easy set-up look at this:
Maybe you're past this too but for the sake of who knows what:
I use the NEC UPD70320-L8 which in short is called V25. This chip has it all. It's a 8088/8086 compatible all in one. Just add ROM, Memory etc. It has a serial port and two multipurpose ports. A third one supplies NMI and three INT pins. It has 20 address lines and separated IO/Memory controlled by it's own. 8 comparator inputs. The ones I use run at 16MHz. There should be other types: V30 and V60. Both more powerfull.
The 70320 runs ROMDOS.

Just an answer.