In the book "TCP/IP Lean" [1], the author states:

"I have used #define in preference to typedef because compilers use better optimisation strategies for their native data types."

Is this true of the Keil C51 compiler?

ie, will C51 generate better-optimised code from source using

#define U8 unsigned char

than from source using

typedef unsigned char U8

[1] Bentham, J.
"TCP/IP Lean"
CMP Books, 2000
ISBN 1-929629-11-7
http://www.iosoft.co.uk/tcplean.htm