It seems you have a language problem, let me try
If we use Port Mapped IO, Directly we can connect to port.
Is this "if I use MMIO can I also use P0 and P2 for other purposes?"
or is it "is it advisable to let port pins drive I/O devices directly?"
or is it "can I connect MMIO directly to I/O devices, but not port driven I/O"

How would be the hardware connections if we want to use Memory mapped IO, and what are Hardware Registers, do we need to initialize them, how can we use them.
is this "how do I connect a device to MMIO?"
or "how do I drive the MMIO from the uC?"

Give an example of what you want to accomplish (e.g. drive a LCD - drive 47 relays - rad some switches) That will make it a lot easier to help you.

The above sounds like your real quesation is "do i use MMIO or use the ports?"
The answer there is "if you have enough pins, there is no reason, whatsoever, to use MMIO."

Please try again and DO remember: more words do not make you appear stupid, it makes you appear specific.

Erik